Home > Products > EGFR & HER3 > Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-156)

Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-EGFR antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-HER3 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Solid tumors therapy.

Specifications
Targets
EGFR & HER3
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Mouse
Target 2
HER3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Solid tumors
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
HER3
Gene ID
UniProt ID
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

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