Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-Fv) (BSGV-H323)

Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (IgG-Fv) is formed by an Immunoglobulin G (IgG) and a fragment variable Fv region, in which the Fc of IgG is engineered by KIH. The Fv region of an anti-EGFR antibody variable domain is fused to the C terminal of an IgG of anti-HER3 antibody, or vice versa. The format retains desired characteristics of intact antibodies. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Solid tumors therapy.

Datasheet

Specifications

Targets

EGFR & HER3

Type

IgG-Fv

Species Reactivity

Human

Target 1

EGFR

Host Animal 1

Mouse

Target 2

HER3

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Targets

Target 1

EGFR

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Target 2

HER3

Gene ID

2065

UniProt ID

P21860

Alternative Names

ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

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