Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (scFv-CH3) contains two chains. The anti-EGFR scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-HER3 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Solid tumors therapy.