Home > Products > EGFR & HER3 > Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (scFv-CH3)

Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (scFv-CH3)  (BSFC-H323)

Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (scFv-CH3) contains two chains. The anti-EGFR scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-HER3 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Solid tumors therapy.

Specifications
Targets
EGFR & HER3
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Mouse
Target 2
HER3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Solid tumors
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
HER3
Gene ID
UniProt ID
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

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