Name: Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (scFv-Fc-scFv)
SKU: BSTF-156
Rating: 5 (1 reviews)

Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-EGFR scFv is fused to the N-terminus of Fc via a hinge region while another anti-HER3 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

EGFR & HER3

Type

scFv-Fc-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Solid tumors

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

EGFR

Gene ID

1956

UniProt ID

P00533

Alternative Names

EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog

Target 2

HER3

Gene ID

2065

UniProt ID

P21860

Alternative Names

ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-EGFR x Anti-HER3 Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-156)

Specifications

Targets

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