Home > Products > EGFR & IGF1R > Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (F(ab')2-scFv2)

Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (F(ab')2-scFv2)  (BABFV-157)

Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-EGFR specificity is fused to the C terminus of the anti-IGF1R Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer therapy.

Specifications
Targets
EGFR & IGF1R
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Mouse
Target 2
IGF1R
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
IGF1R
Gene ID
UniProt ID
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

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