Home > Products > EGFR & IGF1R > Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Minibody)

Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Minibody)  (MiniB-157)

Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Minibody) is designed to be expressed as the anti-EGFR scFv fused to N-terminus of Knob-CH3 domain and the anti-IGF1R scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer therapy.

Specifications

Targets
EGFR & IGF1R
Type
Minibody
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Mouse
Target 2
IGF1R
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer

Targets

Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
IGF1R
Gene ID
UniProt ID
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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