Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (Minibody) is designed to be expressed as the anti-EGFR scFv fused to N-terminus of Knob-CH3 domain and the anti-IGF1R scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer therapy.
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