Home > Products > EGFR & IGF1R > Recombinant Human Anti-EGFR x Human Anti-IGF1R Bispecific Antibody (scFv-Fc)

Recombinant Human Anti-EGFR x Human Anti-IGF1R Bispecific Antibody (scFv-Fc)  (BSCFV-H324)

Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-EGFR specificity or anti-IGF1R specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer therapy.

Specifications
Targets
EGFR & IGF1R
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Mouse
Target 2
IGF1R
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
IGF1R
Gene ID
UniProt ID
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor
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