Home > Products > EGFR & IGF1R > Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (scFv-IgG)

Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (scFv-IgG)  (BSSG-H324)

Recombinant Anti-EGFR x Anti-IGF1R Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-EGFR antibody variable domain are respectively connected to the N terminus of the anti-IGF1R IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer therapy.

Specifications
Targets
EGFR & IGF1R
Type
Appended IgGs
Species Reactivity
Human
Target 1
EGFR
Host Animal 1
Human
Target 2
IGF1R
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Cervical cancer; Breast cancer; Pancreatic cancer
Targets
Target 1
EGFR
Gene ID
UniProt ID
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
IGF1R
Gene ID
UniProt ID
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

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