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Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (VHH-IgG)  (CAT#: BSSG-399)

Recombinant Anti-EGFR x Anti-MET Bispecific Antibody (VHH-IgG) is formed by an IgG and two VHH fragments. The VHHs from an anti-MET antibody variable domain are respectively connected to the N terminus of the anti-EGFR IgG heavy chains or light chains to form VHH-(H)IgG or VHH-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Colorectal cancer; Pancreatic cancer; Head and neck cancer; Non-small cell lung cancer (NSCLC) therapy.
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Specifications

Targets
EGFR & MET
Type
Appended IgGs
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Pancreatic cancer; Head and neck cancer; Non-small cell lung cancer (NSCLC)

Targets

Target 1
EGFR
Gene ID
1956
UniProt ID
P00533
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
Target 2
MET
Gene ID
4233
UniProt ID
A0A024R759
Alternative Names
MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; hepatocyte growth factor receptor; SF receptor; HGF receptor; HGF/SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; met proto-oncogene tyrosine kinase
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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