Name: Recombinant Human Anti-EPCAM x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc)
SKU: KN-0825-N42
Rating: 5 (1 reviews)

Recombinant Human Anti-EPCAM x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) is designed to be expressed as three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-EPCAM antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-4-1BB to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can activate 4-1BB signaling, leading to T cell activation against EPCAM-overexpressing tumors. It is designed for the research of Melanoma; Glioblastoma multiforme (GBM); Non-small cell lung (NSCLC); Colorectal cancer (CRC); Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

EPCAM & 4-1BB

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Melanoma; Glioblastoma multiforme (GBM); Non-small cell lung (NSCLC); Colorectal cancer (CRC); Solid tumors

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

EPCAM

Gene ID

4072

UniProt ID

P16422

Alternative Names

EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein)

Target 2

4-1BB

Gene ID

3604

UniProt ID

Q07011

Alternative Names

CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-EPCAM x Human Anti-4-1BB Bispecific Antibody (Fab-scFv-Fc) (CAT#: KN-0825-N42)

Specifications

Targets

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