Home > Products > FAS & CSPG4 > Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (Diabody-CH3)

Recombinant Human Anti-FAS x Human Anti-CSPG4 Bispecific Antibody (Diabody-CH3)  (BSDBC-H325)

Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-FAS and anti-CSPG4 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can induce targeted apoptosis. It is designed for the research of Melanoma therapy.

Specifications
Targets
FAS & CSPG4
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
FAS
Host Animal 1
Human
Target 2
CSPG4
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Melanoma
Targets
Target 1
FAS
Gene ID
UniProt ID
Alternative Names
APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; FAS; Fas cell surface death receptor
Target 2
CSPG4
Gene ID
UniProt ID
Alternative Names
NG2; Neuron-glial antigen 2; Melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4; CSPG4; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG
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