Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-scFv-Fc) (FABVC-159)

Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-FAS antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CSPG4 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can induce targeted apoptosis. It is designed for the research of Melanoma therapy.

Datasheet INQUIRY

Specifications

Targets

FAS & CSPG4

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Melanoma

Targets

Target 1

FAS

Gene ID

355

UniProt ID

P25445

Alternative Names

APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; FAS; Fas cell surface death receptor

Target 2

CSPG4

Gene ID

1464

UniProt ID

Q6UVK1

Alternative Names

NG2; Neuron-glial antigen 2; Melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4; CSPG4; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-159)

Specifications

Targets

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