Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv-Fc-scFv) (BSTF-159)

Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-FAS scFv is fused to the N-terminus of Fc via a hinge region while another anti-CSPG4 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can induce targeted apoptosis. It is designed for the research of Melanoma therapy.

Datasheet INQUIRY

Specifications

Targets

FAS & CSPG4

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Melanoma

Targets

Target 1

FAS

Gene ID

355

UniProt ID

P25445

Alternative Names

APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; FAS; Fas cell surface death receptor

Target 2

CSPG4

Gene ID

1464

UniProt ID

Q6UVK1

Alternative Names

NG2; Neuron-glial antigen 2; Melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4; CSPG4; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-159)

Specifications

Targets

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