Home > Products > FAS & CSPG4 > Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv4-Ig)

Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv4-Ig)  (FVTIG-159)

Recombinant Anti-FAS x Anti-CSPG4 Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-FAS scFv is fused to the CH1 domain of a heavy chain and another anti-CSPG4 scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can induce targeted apoptosis. It is designed for the research of Melanoma therapy.

Specifications

Targets
FAS & CSPG4
Type
Appended IgGs
Species Reactivity
Human
Target 1
FAS
Host Animal 1
Mouse
Target 2
CSPG4
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Melanoma

Targets

Target 1
FAS
Gene ID
UniProt ID
Alternative Names
APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; FAS; Fas cell surface death receptor
Target 2
CSPG4
Gene ID
UniProt ID
Alternative Names
NG2; Neuron-glial antigen 2; Melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4; CSPG4; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG

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