Name: Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc)
SKU: FABVC-160
Rating: 5 (1 reviews)

Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-FGF2 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VEGF to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Hepatocellular cancer (HCC); Breast cancer; Colon cancer; Lung cancer; Glioma cancer therapy.

Datasheet INQUIRY

Specifications

Targets

FGF2 & VEGF

Type

Fab-scFv/sdAb-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hepatocellular cancer (HCC); Breast cancer; Colon cancer; Lung cancer; Glioma cancer

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

FGF2

Gene ID

2247

UniProt ID

P09038

Alternative Names

FGF; Fibroblast growth factor; FGF2; fibroblast growth factor 2; BFGF; FGFB; FGF-2; HBGF-2

Target 2

VEGF

Gene ID

7422

UniProt ID

P15692

Alternative Names

VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-FGF2 x Anti-VEGF Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-160)

Specifications

Targets

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