Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Diabody-CH3) (BSDBC-H327)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-FGFR1 and anti-KLB antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

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Specifications

Targets

FGFR1 & KLB

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Type 2 diabetes

Targets

Target 1

FGFR1

Gene ID

2260

UniProt ID

P11362

Alternative Names

FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2

Target 2

KLB

Gene ID

152831

UniProt ID

Q86Z14

Alternative Names

klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Diabody-CH3) (CAT#: BSDBC-H327)

Specifications

Targets

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