Name: Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody-Fc)
SKU: BSDBF-161
Rating: 5 (1 reviews)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-FGFR1 and anti-KLB antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

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Specifications

Targets

FGFR1 & KLB

Type

Diabody-Fc

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Type 2 diabetes

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

FGFR1

Gene ID

2260

UniProt ID

P11362

Alternative Names

FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2

Target 2

KLB

Gene ID

152831

UniProt ID

Q86Z14

Alternative Names

klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody-Fc) (CAT#: BSDBF-161)

Specifications

Targets

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