Home > Products > FGFR1 & KLB > Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Diabody-Fc)

Recombinant Human Anti-FGFR1 x Human Anti-KLB Bispecific Antibody (Diabody-Fc)  (BSDBF-H327)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-FGFR1 and anti-KLB antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

Specifications

Targets
FGFR1 & KLB
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
FGFR1
Host Animal 1
Human
Target 2
KLB
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Type 2 diabetes

Targets

Target 1
FGFR1
Gene ID
UniProt ID
Alternative Names
FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2
Target 2
KLB
Gene ID
UniProt ID
Alternative Names
klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

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