Home > Products > FGFR1 & KLB > Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (F(ab')2-scFv2)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (F(ab')2-scFv2)  (BABFV-161)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-FGFR1 specificity is fused to the C terminus of the anti-KLB Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

Specifications
Targets
FGFR1 & KLB
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
FGFR1
Host Animal 1
Mouse
Target 2
KLB
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Type 2 diabetes
Targets
Target 1
FGFR1
Gene ID
UniProt ID
Alternative Names
FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2
Target 2
KLB
Gene ID
UniProt ID
Alternative Names
klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

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