Name: Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (F(ab')2-scFv2)
SKU: BABFV-161
Rating: 5 (1 reviews)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-FGFR1 specificity is fused to the C terminus of the anti-KLB Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

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Specifications

Targets

FGFR1 & KLB

Type

F(ab')2-scFv2

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Type 2 diabetes

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

FGFR1

Gene ID

2260

UniProt ID

P11362

Alternative Names

FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2

Target 2

KLB

Gene ID

152831

UniProt ID

Q86Z14

Alternative Names

klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-161)

Specifications

Targets

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