Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-scFv-Fc)  (FABVC-161)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-FGFR1 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-KLB to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

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