Home > Products > FGFR1 & KLB > Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Miniantibody)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Miniantibody)  (MNAB-161)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Miniantibody) is a fusion protein of two scFv fragments combined with distinct specificity. One scFv of an anti-FGFR1 antibody variable domain is linked to another scFv of an anti-KLB antibody variable domain by a flexible hinge region. This BsAb format has the decreased size and better penetration than conventional IgGs in the clinical diagnostics and potentially therapy. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

Specifications
Targets
FGFR1 & KLB
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
FGFR1
Host Animal 1
Mouse
Target 2
KLB
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Type 2 diabetes
Targets
Target 1
FGFR1
Gene ID
UniProt ID
Alternative Names
FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2
Target 2
KLB
Gene ID
UniProt ID
Alternative Names
klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

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