Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scDiabody-CH3) is a fusion protein of two scDiabodies connected together by a CH3 region. In single-chain Diabodies, an additional connecting linker is introduced between chains of the anti-FGFR1/anti-KLB diabody. The scDiabody with two specificities is fused to each of the CH3 chains to extend half-life. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.