Home > Products > FGFR1 & KLB > Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-CH3)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-CH3)  (BSFC-161)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (scFv-CH3) contains two chains. The anti-FGFR1 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-KLB scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

Specifications
Targets
FGFR1 & KLB
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
FGFR1
Host Animal 1
Mouse
Target 2
KLB
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Type 2 diabetes
Targets
Target 1
FGFR1
Gene ID
UniProt ID
Alternative Names
FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2
Target 2
KLB
Gene ID
UniProt ID
Alternative Names
klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

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