Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Triple Body) (TRIB-H328)

Recombinant Anti-FGFR1 x Anti-KLB Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-FGFR1 antibody are both extended with the scFv fragment from an anti-KLB antibody. This BsAb can bind two factors simultaneously and act as mimetic hormone (FGF21) . It is designed for the research of Type 2 diabetes therapy.

Datasheet

Specifications

Targets

FGFR1 & KLB

Type

Triple Body

Species Reactivity

Human

Target 1

FGFR1

Host Animal 1

Human

Target 2

KLB

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Type 2 diabetes

Targets

Target 1

FGFR1

Gene ID

2260

UniProt ID

P11362

Alternative Names

FGFR1; fibroblast growth factor receptor 1; CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1; basic fibroblast growth factor receptor 1; HBGFR; FMS-like tyrosine kinase 2

Target 2

KLB

Gene ID

152831

UniProt ID

Q86Z14

Alternative Names

klotho beta; BKL; KLB; Beta-klotho; B-klotho; BetaKlotho; klotho beta like 3

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