Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-CH3) (BSDBC-162)

Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-FIXa and anti-FX antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind and dimerize two factors. It acts as mimetic FXIII. It is designed for the research of Hemophilia A therapy.

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Specifications

Targets

FIXa & FX

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hemophilia A

Targets

Target 1

FIXa

Gene ID

2158

UniProt ID

P00740

Alternative Names

F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component

Target 2

Gene ID

2159

UniProt ID

P00742

Alternative Names

F10; coagulation factor X; FX; FXA; factor Xa; prothrombinase; Stuart-Prower factor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-CH3) (CAT#: BSDBC-162)

Specifications

Targets

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