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Recombinant Human Anti-FIXa x Human Anti-FX Bispecific Antibody (Diabody-CH3)  (BSDBC-H328)

Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-FIXa and anti-FX antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind and dimerize two factors. It acts as mimetic FXIII. It is designed for the research of Hemophilia A therapy.

Specifications

Targets
FIXa & FX
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
FIXa
Host Animal 1
Human
Target 2
FX
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Hemophilia A

Targets

Target 1
FIXa
Gene ID
UniProt ID
Alternative Names
F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component
Target 2
FX
Gene ID
UniProt ID
Alternative Names
F10; coagulation factor X; FX; FXA; factor Xa; prothrombinase; Stuart-Prower factor

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