Home > Products > FIXa & FX > Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-Fc)  (FABVC-162)

Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-FIXa antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-FX to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind and dimerize two factors. It acts as mimetic FXIII. It is designed for the research of Hemophilia A therapy.

Specifications

Targets
FIXa & FX
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
FIXa
Host Animal 1
Mouse
Target 2
FX
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Hemophilia A

Targets

Target 1
FIXa
Gene ID
UniProt ID
Alternative Names
F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component
Target 2
FX
Gene ID
UniProt ID
Alternative Names
F10; coagulation factor X; FX; FXA; factor Xa; prothrombinase; Stuart-Prower factor

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