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Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fv-IgG)  (BSDG-162)

Recombinant Anti-FIXa x Anti-FX Bispecific Antibody (Fv-IgG) is an appended IgG format, which has 2+2 antigen-binding valency. This dual variable domain IgG is generated by appending variable domains of an anti-FIXa IgG with similar domains from an anti-FX antibody via short peptide linkers, or vice versa. This BsAb can bind and dimerize two factors. It acts as mimetic FXIII. It is designed for the research of Hemophilia A therapy.

Specifications

Targets
FIXa & FX
Type
Appended IgGs
Species Reactivity
Human
Target 1
FIXa
Host Animal 1
Mouse
Target 2
FX
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Hemophilia A

Targets

Target 1
FIXa
Gene ID
UniProt ID
Alternative Names
F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component
Target 2
FX
Gene ID
UniProt ID
Alternative Names
F10; coagulation factor X; FX; FXA; factor Xa; prothrombinase; Stuart-Prower factor

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Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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