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Recombinant Anti-FN1 x Anti-HSG Bispecific Antibody (Diabody-CH3)  (BSDBC-163)

Recombinant Anti-FN1 x Anti-HSG Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-FN1 and anti-HSG antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can be used in pretargeting system of PET, radioimaging or radiotherapy. It can mediate targeting of radioactivity to tumor cells. It is designed for the research of Solid tumors imaging and therapy.

Specifications

Targets
FN1 & HSG
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
FN1
Host Animal 1
Mouse
Target 2
HSG
Host Animal 2
Mouse
Application
FuncS; Pretargeting system for radioimaging and radiotherapy
Related Disease
Solid tumors

Targets

Target 1
FN1
Gene ID
UniProt ID
Alternative Names
FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; Cold-insoluble globulin; Migration-stimulating factor
Target 2
HSG
Alternative Names
histaminyl-succinyl-glycine; HSG

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