Home > Products > gp40 & TFRC > Recombinant Anti-gp40 x Anti-TFRC Bispecific Antibody (scFv-Fc-scFv)

Recombinant Anti-gp40 x Anti-TFRC Bispecific Antibody (scFv-Fc-scFv)  (BSTF-164)

Recombinant Anti-gp40 x Anti-TFRC Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-gp40 scFv is fused to the N-terminus of Fc via a hinge region while another anti-TFRC scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can bind two tumor antigens simultaneously. It is designed for the research of Colon cancer; Ovarian cancer therapy.

Specifications
Targets
gp40 & TFRC
Type
scFv-Fc-scFv
Species Reactivity
Human
Target 1
gp40
Host Animal 1
Mouse
Target 2
TFRC
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colon cancer; Ovarian cancer
Targets
Target 1
gp40
Alternative Names
gp40; glycoprotein 40; adenocarcinoma-associated antigen
Target 2
TFRC
Gene ID
UniProt ID
Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71); IMD46

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