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Recombinant Anti-gp40 x Anti-TFRC Bispecific Antibody (scFv4-Ig)  (FVTIG-164)

Recombinant Anti-gp40 x Anti-TFRC Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-gp40 scFv is fused to the CH1 domain of a heavy chain and another anti-TFRC scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can bind two tumor antigens simultaneously. It is designed for the research of Colon cancer; Ovarian cancer therapy.

Specifications

Targets
gp40 & TFRC
Type
Appended IgGs
Species Reactivity
Human
Target 1
gp40
Host Animal 1
Mouse
Target 2
TFRC
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Colon cancer; Ovarian cancer

Targets

Target 1
gp40
Alternative Names
gp40; glycoprotein 40; adenocarcinoma-associated antigen
Target 2
TFRC
Gene ID
UniProt ID
Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71); IMD46

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