Name: Recombinant Human Anti-GPC3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv)
SKU: KN-0825-N16
Rating: 5 (1 reviews)

Recombinant Human Anti-GPC3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) is designed to be expressed as a LC and an extended HC with scFv moiety linked to the C terminus. The anti-4-1BB scFvs are fused to the C terminus of the anti-GPC3 IgG-Fc chain. It is a symmetric bispecific and tetravalent molecule, bivalent for each antigen specificity, 2+2 antigen-binding valency. This BsAb can activate 4-1BB signaling, leading to T cell activation against HER2-overexpressing tumors. It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet INQUIRY

Specifications

Targets

GPC3 & 4-1BB

Type

IgG-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Hepatocellular cancer (HCC); Melanoma

Host Animal 1

Human

Host Animal 2

Human

Targets

Target 1

GPC3

Gene ID

2719

UniProt ID

P51654

Alternative Names

SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2; GPC3; glypican 3

Target 2

4-1BB

Gene ID

3604

UniProt ID

Q07011

Alternative Names

CD137; Cluster of Differentiation 137; 4-1BB; 4-1BB Receptor; ILA; Induced by Lymphocyte Activation; T-cell Antigen 4-1BB Homolog; CDw137; IMD109; 4-1BB ligand receptor; Tumor necrosis factor receptor superfamily member 9; T-cell antigen ILA

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-GPC3 x Human Anti-4-1BB Bispecific Antibody (IgG(H)-scFv) (CAT#: KN-0825-N16)

Specifications

Targets

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