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Recombinant Human Anti-HER2 x Human Anti-HER3 Bispecific Antibody (Fab-Fv)  (FABFV-H332)

Recombinant Anti-HER2 x Anti-HER3 Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-HER2 antibody are fused with the VL and VH domains of an anti-HER3 antibody respectively. It can form natural in vivo heterodimerization. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors therapy.

Datasheet
Specifications
Targets
HER2 & HER3
Type
Fab-Fv
Species Reactivity
Human
Target 1
HER2
Host Animal 1
Human
Target 2
HER3
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Breast cancer; Gastric cancer; Prostate cacncer; Ovarian cancer; Solid tumors
Targets
Target 1
HER2
Gene ID
2064
UniProt ID
P04626
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Target 2
HER3
Gene ID
2065
UniProt ID
P21860
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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