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Recombinant Human Anti-HER2 x Anti-VEGF Bispecific Antibody (Triple Body)  (TRIB-H334)

Recombinant Anti-HER2 x Anti-VEGF Bispecific Antibody (Triple Body) is designed to be expressed as two polypeptide chains respectively. The Fd fragment and LC from an anti-HER2 antibody are both extended with the scFv fragment from an anti-VEGF antibody. This BsAb can bind two factors simultaneously and inhibit cell proliferation. It is designed for the research of Colorectal cancer; Breast cancer; Lung cancer; Renal cell cancer (RCC); Glioma cancer; Glioblastoma; Ovarian cancer therapy.

Specifications

Targets
HER2 & VEGF
Type
Triple Body
Species Reactivity
Human
Target 1
HER2
Host Animal 1
Human
Target 2
VEGF
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer; Breast cancer; Lung cancerRenal cell cancer (RCC) Glioma cancer; GlioblastomaOvarian cancer

Targets

Target 1
HER2
Gene ID
UniProt ID
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; human epidermal growth factor receptor 2; neuro/glioblastoma derived oncogene homolog; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Target 2
VEGF
Gene ID
UniProt ID
Alternative Names
VEGFA; vascular endothelial growth factor A; VPF; VEGF; MVCD1; vascular permeability factor

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