Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-VHH-Fc) (FABVC-406)

Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-VHH-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-HER3 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the VHH of anti-IGF1R to the Fc-hole domain, or vice versa. The Fab-Fc and VHH-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Pancreatic cancer; Hepatocellular carcinoma (HCC) therapy.

Datasheet INQUIRY

Specifications

Targets

HER3 & IGF1R

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Pancreatic cancer; Hepatocellular carcinoma (HCC)

Targets

Target 1

HER3

Gene ID

2065

UniProt ID

P21860

Alternative Names

ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

Target 2

IGF1R

Gene ID

3480

UniProt ID

P08069

Alternative Names

IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (Fab-VHH-Fc) (CAT#: FABVC-406)

Specifications

Targets

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