Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-HER3 antibody variable domain is fused to CH1 and the other scFv from an anti-IGF1R antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Pancreatic cancer; Hepatocellular carcinoma (HCC) therapy.
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