Home > Products > HER3 & IGF1R > Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-CH3)

Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-CH3)  (BSFC-169)

Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-CH3) contains two chains. The anti-HER3 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-IGF1R scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Pancreatic cancer; Hepatocellular carcinoma (HCC) therapy.

Specifications

Targets
HER3 & IGF1R
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
HER3
Host Animal 1
Mouse
Target 2
IGF1R
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Pancreatic cancer; Hepatocellular carcinoma (HCC)

Targets

Target 1
HER3
Gene ID
UniProt ID
Alternative Names
ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
Target 2
IGF1R
Gene ID
UniProt ID
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

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