Recombinant Anti-HER3 x Anti-IGF1R Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-HER3 antibody variable domain are respectively connected to the N terminus of the anti-IGF1R IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can bind and inactivate two receptors simultaneously. It is designed for the research of Pancreatic cancer; Hepatocellular carcinoma (HCC) therapy.
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