Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-CH3) (BSFC-H342)

Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv-CH3) contains two chains. The anti-IL1α scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-IL1β scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can block two proinﬂammatory cytokines simultaneously. It is designed for the research of Osteoarthritis (OA) therapy.

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Specifications

Targets

IL1α & IL1β

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Osteoarthritis (OA)

Targets

Target 1

IL1α

Gene ID

3552

UniProt ID

P01583

Alternative Names

IL1; IL-1A; IL1F1; IL1-ALPHA; Interleukin 1 alpha; hematopoietin 1; IL1α

Target 2

IL1β

Gene ID

3553

UniProt ID

P01584

Alternative Names

IL-1; IL1F2; IL1-BETA; IL1β; Interleukin-1β; IL-1β

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-CH3) (CAT#: BSFC-H342)

Specifications

Targets

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