Home > Products > IL1α & IL1β > Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-IgG)

Recombinant Human Anti-IL1α x Human Anti-IL1β Bispecific Antibody (scFv-IgG)  (BSSG-H342)

Recombinant Anti-IL1α x Anti-IL1β Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-IL1α antibody variable domain are respectively connected to the N terminus of the anti-IL1β IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can block two proinflammatory cytokines simultaneously. It is designed for the research of Osteoarthritis (OA) therapy.

Specifications

Targets
IL1α & IL1β
Type
Appended IgGs
Species Reactivity
Human
Target 1
IL1α
Host Animal 1
Human
Target 2
IL1β
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Osteoarthritis (OA)

Targets

Target 1
IL1α
Gene ID
UniProt ID
Alternative Names
IL1; IL-1A; IL1F1; IL1-ALPHA; Interleukin 1 alpha; hematopoietin 1; IL1α
Target 2
IL1β
Gene ID
UniProt ID
Alternative Names
IL-1; IL1F2; IL1-BETA; IL1β; Interleukin-1β; IL-1β

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