Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Diabody-CH3) (BSDBC-H336)

Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-IL12 and anti-IL18 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Arthritis therapy.

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Specifications

Targets

IL12 & IL18

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Arthritis

Targets

Target 1

IL12

Gene ID

3592

UniProt ID

P29459

Alternative Names

P35; CLMF; NFSK; NKSF1; IL-12A; IL12; IL-12; interleukin 12A

Target 2

IL18

Gene ID

3606

UniProt ID

A0A024R3E0

Alternative Names

IGIF; IL-18; IL-1g; IL1F4; interleukin 18; IL18

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (Diabody-CH3) (CAT#: BSDBC-H336)

Specifications

Targets

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