Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-Fc) (FABVC-171)

Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-IL12 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-IL18 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Arthritis therapy.

Datasheet INQUIRY

Specifications

Targets

IL12 & IL18

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Arthritis

Targets

Target 1

IL12

Gene ID

3592

UniProt ID

P29459

Alternative Names

P35; CLMF; NFSK; NKSF1; IL-12A; IL12; IL-12; interleukin 12A

Target 2

IL18

Gene ID

3606

UniProt ID

A0A024R3E0

Alternative Names

IGIF; IL-18; IL-1g; IL1F4; interleukin 18; IL18

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-171)

Specifications

Targets

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