Home > Products > IL12 & IL18 > Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (IgG(L)-scFv)

Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (IgG(L)-scFv)  (IGLFV-H336)

Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (IgG(L)-scFv) is formed by an IgG and two scFv moieties. The scFv fragments from an anti-IL12 antibody are fused to the C terminus of an anti-IL18 IgG light (L) chains, or vice versa. It is a type of appended IgGs, which is bispecific and tetravalent (2+2 antigen-binding valency). This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Arthritis therapy.

Specifications
Targets
IL12 & IL18
Type
Appended IgGs
Species Reactivity
Human
Target 1
IL12
Host Animal 1
Human
Target 2
IL18
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Arthritis
Targets
Target 1
IL12
Gene ID
UniProt ID
Alternative Names
P35; CLMF; NFSK; NKSF1; IL-12A; IL12; IL-12; interleukin 12A
Target 2
IL18
Gene ID
UniProt ID
Alternative Names
IGIF; IL-18; IL-1g; IL1F4; interleukin 18; IL18
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