Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scDiabody-CH3) is a fusion protein of two scDiabodies connected together by a CH3 region. In single-chain Diabodies, an additional connecting linker is introduced between chains of the anti-IL12/anti-IL18 diabody. The scDiabody with two specificities is fused to each of the CH3 chains to extend half-life. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Arthritis therapy.