Home > Products > IL12 & IL18 > Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-CH3)

Recombinant Human Anti-IL12 x Human Anti-IL18 Bispecific Antibody (scFv-CH3)  (BSFC-H336)

Recombinant Anti-IL12 x Anti-IL18 Bispecific Antibody (scFv-CH3) contains two chains. The anti-IL12 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-IL18 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can bind and inactivate two ligands simultaneously. It is designed for the research of Arthritis therapy.

Specifications

Targets
IL12 & IL18
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
IL12
Host Animal 1
Mouse
Target 2
IL18
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Arthritis

Targets

Target 1
IL12
Gene ID
UniProt ID
Alternative Names
P35; CLMF; NFSK; NKSF1; IL-12A; IL12; IL-12; interleukin 12A
Target 2
IL18
Gene ID
UniProt ID
Alternative Names
IGIF; IL-18; IL-1g; IL1F4; interleukin 18; IL18

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