Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-Fc-scFv) (BSTF-173)

Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-IL13 scFv is fused to the N-terminus of Fc via a hinge region while another anti-IL4 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can block two proinﬂammatory cytokines simultaneously. It is designed for the research of Idiopathic pulmonary fibrosis therapy.

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Specifications

Targets

IL13 & IL4

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Idiopathic pulmonary fibrosis

Targets

Target 1

IL13

Gene ID

3596

UniProt ID

P35225

Alternative Names

IL13; interleukin 13; P600; IL-13; interleukin-13

Target 2

IL4

Gene ID

3565

UniProt ID

D4HNR6

Alternative Names

IL4; interleukin 4; BSF1; IL-4; BCGF1; BSF-1; BCGF-1; interleukin-4; binetrakin; pitrakinra; B cell growth factor 1; interleukin 4 variant 2; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-IL13 x Anti-IL4 Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-173)

Specifications

Targets

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