Home > Products > IL17 & TNF > Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv)

Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv)  (FABFV-175)

Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-IL17 antibody are fused with the VL and VH domains of an anti-TNF antibody respectively. It can form natural in vivo heterodimerization. This BsAb can block two proinflammatory cytokines simultaneously. It is designed for the research of Rheumatoid arthritis (RA); Plaque psoriasis therapy.

Specifications

Targets
IL17 & TNF
Type
Fab-Fv
Species Reactivity
Human
Target 1
IL17
Host Animal 1
Mouse
Target 2
TNF
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Rheumatoid arthritis (RA); Plaque psoriasis

Targets

Target 1
IL17
Gene ID
UniProt ID
Alternative Names
IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Target 2
TNF
Gene ID
UniProt ID
Alternative Names
TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

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