Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (Minibody) is designed to be expressed as the anti-IL17 scFv fused to N-terminus of Knob-CH3 domain and the anti-TNF scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can block two proinflammatory cytokines simultaneously. It is designed for the research of Rheumatoid arthritis (RA); Plaque psoriasis therapy.
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