Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH3) (BSFC-175)

Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH3) contains two chains. The anti-IL17 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-TNF scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can block two proinﬂammatory cytokines simultaneously. It is designed for the research of Rheumatoid arthritis (RA); Plaque psoriasis therapy.

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Specifications

Targets

IL17 & TNF

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Rheumatoid arthritis (RA); Plaque psoriasis

Targets

Target 1

IL17

Gene ID

3605

UniProt ID

Q16552

Alternative Names

IL17A; interleukin 17A; IL17; CTLA8; IL-17; IL-17A; interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

Target 2

TNF

Gene ID

7124

UniProt ID

P01375

Alternative Names

TNF; tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNFα; cachectin; APC1 protein; TNF, monocyte-derived; TNF-α; TNF, macrophage-derived; tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-IL17 x Anti-TNF Bispecific Antibody (scFv-CH3) (CAT#: BSFC-175)

Specifications

Targets

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